Beilstein J. Org. Chem.2016,12, 1585–1589, doi:10.3762/bjoc.12.154
experimental conditions and with great economic advantages.
Keywords: deuteration; deuteriumatomtransfer; radical and/or organometallic chemistry; titanocene; Introduction
Deuterium is a stable isotope of hydrogen with 0.015% natural abundance broadly used in organic chemistry, pharmacology, organometallic
1).
In presence of D2O these radicals (pathway A) can be reduced into deuterated compounds. The reduction can proceed via hydrolysis of an organometallic alkyl-TiIV intermediate (Scheme 2, pathway A1) or via deuterium-atomtransfer (DAT) from D2O to radicals (Scheme 2, pathway A2). In the case of
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Graphical Abstract
Scheme 1:
Formation of reaction intermediates susceptible of being reduced by Cp2TiCl/Mn/D2O.